Tempus AI, Inc.

Tempus AI, Inc. (TEM) Market Cap

Tempus AI, Inc. has a market capitalization of $9.74B.

Financials based on reported quarter end 2025-12-31

Price: $55.87

1.45 (2.66%)

Market Cap: 9.74B

NASDAQ · time unavailable

CEO: Eric Lefkofsky

Sector: Healthcare

Industry: Medical - Healthcare Information Services

IPO Date: 2024-06-14

Website: https://www.tempus.com

Tempus AI, Inc. (TEM) - Company Information

Market Cap: 9.74B · Sector: Healthcare

Tempus AI, Inc. operates as a healthcare technology company. It engages in providing next generation sequencing diagnostics, polymerase chain reaction profiling, molecular genotyping, and other anatomic and molecular pathology testing to healthcare providers, pharmaceutical companies, biotechnology companies, researchers, and other third parties. The company offers Insights, a license library of linked clinical, molecular, and imaging de-identified data, as well as a suite of analytical services to analytic and cloud-and-compute tools to pharmaceutical and biotechnology companies; and Trials that provides clinical trial matching services to pharmaceutical companies. In addition, it operates Next; Algos, a suite of algorithmic tests in oncology; Hub, a desktop and mobile platform for ordering, managing, and receiving tests and patient results; and Lens, a platform for researchers and scientists to find, access, and analyze Tempus data. The company has a strategic collaborations agreement with AstraZeneca and Pathos AI, Inc. to develop therapeutic programs in oncology. The company was formerly known as Tempus Labs, Inc. and changed its name to Tempus AI, Inc. in January 2023. Tempus AI, Inc. was incorporated in 2015 and is headquartered in Chicago, Illinois.

Analyst Sentiment

69%
Buy

Based on 18 ratings

Analyst 1Y Forecast: $86.36

Average target (based on 3 sources)

Consensus Price Target

Low

$59

Median

$90

High

$105

Average

$86

Potential Upside: 54.2%

Price & Moving Averages

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AI-Generated Research: This report is for informational purposes only.

📘 TEMPUS AI INC CLASS A (TEM) — Investment Overview

🧩 Business Model Overview

Tempus AI Inc (TEM) operates as a precision medicine technology company, specializing in the application of artificial intelligence and machine learning to the vast and complex world of healthcare data. The company's core strategy is to leverage its proprietary data platform, integrating multimodal datasets—including genomic, clinical, imaging, and molecular data—into actionable insights for clinicians, researchers, and biopharmaceutical companies. Tempus’s mission is to advance precision medicine by making the world's healthcare information accessible and useful, empowering healthcare providers to deliver personalized care. The company focuses on multiple therapeutic areas, with a notable emphasis on oncology, cardiology, neurology, and infectious diseases. Its modular software platform, data analytics tools, and AI-driven clinical decision support systems underpin its service offerings.

💰 Revenue Streams & Monetisation Model

Tempus AI's monetisation strategy is multifaceted, reflecting a dual-market approach targeting both healthcare providers and life sciences enterprises. Primary revenue streams include: - **Clinical Testing and Diagnostic Services:** Tempus provides molecular diagnostics, genomic sequencing, and AI-based interpretation for individual patients. Revenue is generated through test volume, typically reimbursed by insurers, hospitals, or direct payment. - **Data Analytics and Platform Licensing:** The company's biopharma solutions offer large-scale data analytics, trial matching, and research services. Pharmaceutical and biotech partners pay for access to Tempus’ datasets, analytics tools, and R&D support services to enhance drug development and post-market surveillance. - **AI-Driven Software Tools:** Subscription and license fees are derived from AI-driven decision support and real-world evidence platforms—often integrated into hospital systems or leveraged by CROs and providers. - **Collaborative Research and Custom Solutions:** Tempus enters into collaborative projects that include custom data curation, data sharing agreements, joint IP development, and tailored analytics, generating bespoke revenue contracts. The company’s strategy emphasizes recurring revenues (licenses, subscriptions), complemented by variable clinical testing fees and project-based partnerships.

🧠 Competitive Advantages & Market Positioning

Tempus AI stands at the intersection of clinical practice and data science, harnessing several structural advantages: - **Scale and Breadth of Proprietary Data:** Through deep partnerships with providers, Tempus collects, curates, and integrates one of the industry’s most expansive, multimodal, and longitudinal datasets. The size, diversity, and depth of this proprietary data asset constitute a formidable barrier to entry for competitors. - **AI/ML Platform Integration:** Tempus’s AI-driven analytics are closely embedded into clinical workflows, enhancing physician adoption and patient reach. - **Strategic Relationships:** Collaboration with top-tier academic centers, integrated delivery networks, and leading pharmaceutical firms strengthens its data acquisition and platform embedding. - **End-to-End Solutions:** The company is positioned to serve both the clinical and research markets, enabling unique cross-pollination of insights between direct patient care and drug development. - **Regulatory and Compliance Acumen:** Emphasis on HIPAA-compliance, data security, and clinical-grade analytics supports trust and regulatory readiness. In the landscape of healthcare technology, Tempus is recognized as a leading enabler of personalized oncology, and is rapidly expanding to adjacent disease areas. Contenders include established health informatics providers, genomic testing companies, and newer AI healthcare entrants, but few competitors offer comparable integration of data, analytics, and clinical utility.

🚀 Multi-Year Growth Drivers

Several secular and company-specific growth drivers are firmly in play: - **Expansion of Precision Medicine:** Rising adoption of genomic sequencing and molecular profiling in clinical practice expands the addressable market for Tempus’s solutions. - **Growth of Real-World Evidence (RWE):** Biopharmaceutical demand for real-world clinical data and AI analytics is accelerating, driven by the need for effective drug discovery, clinical trial optimization, and post-market surveillance. - **Integration into Clinical Workflows:** Deeper embedding of decision support tools in hospital EHR systems increases clinician adoption and drives test volumes. - **Pipeline Initiatives in New Therapeutic Areas:** Beyond oncology, Tempus is ramping offerings in cardiology, neurology, and infectious disease, targeting incremental share in large untapped markets. - **Globalization and Partnerships:** Ongoing expansion through international partnerships and collaborations may unlock new markets for data and testing services. - **Regulatory Tailwinds:** Increasing payer coverage for molecular diagnostics and AI-assisted decision support enhances reimbursement stability and broadens access.

⚠ Risk Factors to Monitor

Despite compelling growth prospects, several risks are pertinent: - **Data Privacy and Regulatory Compliance:** Handling sensitive patient health data entails acute regulatory scrutiny; any breach or regulatory lapse could carry financial and reputational repercussions. - **Payer Reimbursement Risk:** Shifts in reimbursement frameworks and payer attitudes toward molecular diagnostics and data-driven health tools can impact revenues and margins. - **Competitive Dynamics:** While Tempus boasts substantial data assets, the competitive environment is evolving rapidly, with both entrenched diagnostics firms and tech giants targeting healthcare analytics. - **Integration and Adoption Barriers:** Successful integration of AI tools into clinical workflows depends on clinician trust, ongoing validation, and adaptation to shifting standards of care. - **Capital Requirements:** Continued investment in R&D, data infrastructure, and commercial expansion could require significant capital, especially as the company broadens its addressable market.

📊 Valuation & Market View

Tempus AI is fundamentally valued as a high-growth, data-driven technology platform within the healthcare sector. Valuation is frequently anchored to revenue multiples, justified by the company’s combination of rapid top-line growth, recurring revenue visibility, and a large total addressable market. Investors typically compare Tempus to other genomics, healthcare informatics, and AI-enabled clinical diagnostics peers—firms such as Flatiron Health, Guardant Health, Foundation Medicine, and newer digital health entrants. Key valuation levers include operating leverage as the core technology scales, expansion of high-margin data & analytics services versus lower-margin testing, and the pace of adoption across new disease verticals. Potential for long-term margin expansion exists as more revenues shift toward recurring, software- and data-based offerings. Market sentiment around Tempus is influenced by its execution in commercializing novel data products, sustaining its data advantage, and maintaining regulatory compliance. Upside scenarios hinge on market leadership in precision oncology and rapid expansion into multi-therapeutic platforms; downside risks pertain to competitive share loss and adverse regulatory or reimbursement environments.

🔍 Investment Takeaway

Tempus AI Inc. represents a differentiated opportunity at the confluence of technology, big data, and healthcare. Its robust proprietary datasets, AI platform integration, and strong ecosystem relationships underpin a business model poised for multi-year expansion. As the precision medicine paradigm becomes increasingly embedded in standard care, Tempus stands to benefit from secular growth in genomic testing volumes, biopharma data services, and clinical AI tool adoption. While execution risks, regulatory challenges, and industry competition remain salient, the company is positioned as a potential long-term leader in health data infrastructure—a platform business model generating multiple recurring revenue streams. For investors seeking exposure to the digital transformation of healthcare and the rise of precision medicine, Tempus AI warrants consideration within a diversified, risk-aware portfolio.

⚠ AI-generated — informational only. Validate using filings before investing.

Fundamentals Overview

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📊 AI Financial Analysis

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Earnings Data: Q Ending 2025-12-31

"TEM reported a quarterly revenue of $367.2 million with a net loss of $54.2 million, resulting in an EPS of -$0.30. The company's net margin was notably negative, reflecting operational challenges. The free cash flow was -$203.1 million, indicating liquidity pressure as cash outflows exceeded operating cash inflows. On a year-over-year basis, revenue showed limited growth. The company’s high debt-to-equity ratio suggests significant leverage, while the balance sheet totaled $2.27 billion in assets. Analysts have set a consensus price target of $89.88, with bearish sentiment indicated by a low FCF and negative EPS. Capital expenditures were moderate, but issuance of $195.5 million in stock highlights the reliance on equity financing. With no dividends or buybacks, direct shareholder returns are negligible. The company's financial performance underscores a need for strategic adjustments to improve profitability and investor confidence."

Revenue Growth

Caution

Revenue growth remains modest with limited year-over-year increase, driven by a challenging market.

Profitability

Neutral

Operating margins and EPS reflect continuous losses, indicating inefficiencies in cost management.

Cash Flow Quality

Neutral

Negative free cash flow and reliance on stock issuance for financing operations raise liquidity concerns.

Leverage & Balance Sheet

Neutral

High net debt and a significant debt-to-equity ratio impose financial burdens and limit flexibility.

Shareholder Returns

Neutral

Absence of dividends and buybacks result in minimal direct returns to shareholders.

Analyst Sentiment & Valuation

Caution

Mixed analyst sentiment with a consensus target suggesting potential growth, but current fundamentals are weak.

Disclaimer:This analysis is AI-generated for informational purposes only. Accuracy is not guaranteed and this does not constitute financial advice.

Tempus delivered strong Q4 and 2025 performance with accelerating diagnostics, rapid MRD traction, and a faster-growing data business supported by high NRR and record TCV. Management guided to ~$1.59B revenue and positive adjusted EBITDA in 2026, citing robust bookings and the early success of its oncology foundation model. Strategic AI and FDA initiatives (xT CDx migration, xF submission) and deep provider integration underpin continued share gains, while reimbursement for MRD and moderating hereditary growth remain watch points. Overall tone was confident and growth-oriented.

Growth

  • Core revenue up >33% y/y; consolidated (incl. Ambry) higher
  • Diagnostics: Oncology unit volume +29% y/y; Hereditary +23% y/y
  • MRD volumes +56% q/q to ~4,700 tests (highly constrained sales effort)
  • Data (Insights/licensing) up 69% in the quarter including one-time AstraZeneca warrant impact
  • Net revenue retention 126%; Total contract value (TCV) >$1.1B and rising faster than revenue
  • Management projects ~40% data growth in Q1 2026

Business Development

  • Launched Paige Predict to generate insights when sequencing is QNS/fails
  • Introduced Immune Profile Score; continued stacking of AI-driven diagnostic insights
  • Foundation model for oncology met Q1 benchmarks for AstraZeneca; AZ testing underway
  • Expanded compute: >1,000 H200 GPUs for oncology model; additional >500 GB200 GPUs for broader multimodal models
  • Submitted xF (liquid biopsy) to FDA; plan to migrate xT to FDA-approved CDx with majority of volume by end-2026
  • Heme whole-genome offering slated to go live in 2026
  • Largest pharma clients continue to renew/expand multi-year data contracts

Financials

  • Guiding 2026 revenue to ~$1.59B with ~+$65M adjusted EBITDA
  • Q4 ASP ~$1,640, up ~$40 q/q; >$500 potential ASP uplift over time from mix (xT CDx migration, future xF FDA approval, payer gains)
  • Balance sheet described as in ‘great shape’
  • Data business scale now ~4x 2021 levels; strong bookings support growth

Capital & Funding

  • Ongoing investment in AI compute clusters (H200 and GB200) to train multimodal foundation models
  • AstraZeneca warrant provided a one-time uplift to Insights revenue in Q4
  • Ambry acquisition (Hereditary) continues to bolster consolidated scale; no new capital raises disclosed

Operations & Strategy

  • Dual moat: proprietary multimodal clinical-genomic dataset (~450 PB) and embedded distribution (5,500+ hospitals; 8,500+ ordering oncologists)
  • Diagnostic ‘contextualization’ strategy integrates AI insights across xT, xR, xF, xH, xE to improve clinical utility and turnaround
  • MRD commercialization intentionally gated; broader rollout planned as reimbursement matures
  • Deep EHR integrations and workflow embedding to drive adoption
  • Long-term revenue growth target ~25% supported by diagnostics scale and accelerating data applications

Market & Outlook

  • Management expects a ‘phenomenal’ 2026 with accelerating data demand from pharma
  • Starting 2026 with strongest revenue visibility to date due to robust bookings/TCV tied to in-year delivery
  • Oncology volumes off to a strong start in Q1 2026; Hereditary growth to moderate (high-teens long-term) with intra-year lumpiness
  • AI-driven insights expected to increasingly enhance both diagnostics and data value propositions

Risks Or Headwinds

  • MRD reimbursement not yet broad; sales intentionally constrained pending coverage progress
  • Hereditary testing growth moderating and potentially lumpy as share gains are lapped
  • Regulatory timelines/approvals (xT CDx migration; xF FDA clearance) could shift ASP uplift timing
  • Competitive intensity from established diagnostics peers and new AI entrants in healthcare
  • One-time items (e.g., AZ warrant) affect quarterly comparability

Sentiment: POSITIVE

Note: This summary was synthesized by AI from the TEM Q4 2025 earnings transcript. Financial data is complex; please verify all metrics against official SEC filings before making investment decisions.

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SEC Filings (TEM)

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