Current Net Margin
-112.81%
Ionis Pharmaceuticals, Inc. currently has a net profit margin of -112.81%.
Financial Fundamentals
IONS • Quarterly Data • 5Y View
Historical Margin Data
| Date | Rev ($B) | NI ($B) | Net Margin | Change (bps) |
|---|---|---|---|---|
| 2025-12-31 | 0.20 | -0.23 | -112.81% | ▼3075 |
| 2025-10-28 | 0.16 | -0.13 | -82.06% | ▼10939 |
| 2025-06-30 | 0.45 | 0.12 | 27.33% | ▲13898 |
| 2025-03-31 | 0.13 | -0.15 | -111.64% | ▼6559 |
| 2024-12-31 | 0.23 | -0.10 | -46.05% | ▲5893 |
| 2024-09-30 | 0.13 | -0.14 | -104.98% | ▼7556 |
| 2024-06-30 | 0.23 | -0.07 | -29.42% | ▲9008 |
| 2024-03-31 | 0.12 | -0.14 | -119.50% | ▼11665 |
| 2023-12-31 | 0.32 | -0.01 | -2.85% | ▲9937 |
| 2023-09-30 | 0.14 | -0.15 | -102.22% | ▼5695 |
| 2023-06-30 | 0.19 | -0.09 | -45.27% | ▲4998 |
| 2023-03-31 | 0.13 | -0.12 | -95.25% | ▼6073 |
| 2022-12-31 | 0.15 | -0.05 | -34.52% | ▼511 |
| 2022-09-30 | 0.16 | -0.05 | -29.41% | ▲4917 |
| 2022-06-30 | 0.13 | -0.11 | -78.58% | ▼3266 |
| 2022-03-31 | 0.14 | -0.07 | -45.92% | ▼9696 |
| 2021-12-31 | 0.44 | 0.22 | 51.05% | ▲11301 |
| 2021-09-30 | 0.13 | -0.08 | -61.96% | ▲235 |
| 2021-06-30 | 0.13 | -0.08 | -64.31% | ▲1621 |
| 2021-03-31 | 0.11 | -0.09 | -80.52% | ▲3670 |
| 2020-12-31 | 0.29 | -0.34 | -117.22% | ▼10194 |
| 2020-09-30 | 0.16 | -0.02 | -15.28% | ▲233 |
| 2020-06-30 | 0.15 | -0.03 | -17.61% | ▲1210 |
| 2020-03-31 | 0.13 | -0.04 | -29.71% | ▼6707 |
| 2019-12-31 | 0.49 | 0.18 | 37.36% | ▲2177 |
| 2019-09-30 | 0.17 | 0.03 | 15.58% | ▲1612 |
| 2019-06-30 | 0.16 | -0.00 | -0.53% | ▼2895 |
| 2019-03-31 | 0.30 | 0.08 | 28.41% | ▼13819 |
| 2018-12-31 | 0.19 | 0.32 | 166.61% | ▲16974 |
| 2018-09-30 | 0.15 | -0.00 | -3.14% | ▲3114 |
| 2018-06-30 | 0.12 | -0.04 | -34.27% | ▼3329 |
| 2018-03-31 | 0.14 | -0.00 | -0.98% | ▼258 |
| 2017-12-31 | 0.17 | 0.00 | 1.59% | ▲380 |
| 2017-09-30 | 0.12 | -0.00 | -2.21% | ▲54 |
| 2017-06-30 | 0.11 | -0.00 | -2.75% | ▼1049 |
| 2017-03-31 | 0.12 | 0.01 | 7.74% | ▼839 |
| 2016-12-31 | 0.16 | 0.03 | 16.13% | ▲950 |
| 2016-09-30 | 0.11 | 0.01 | 6.63% | ▲15442 |
| 2016-06-30 | 0.04 | -0.06 | -147.79% | ▲2284 |
| 2016-03-31 | 0.04 | -0.06 | -170.63% | ▼3211 |
| 2015-12-31 | 0.05 | -0.07 | -138.52% | ▼6568 |
| 2015-09-30 | 0.05 | -0.04 | -72.83% | ▼10243 |
| 2015-06-30 | 0.12 | 0.04 | 29.60% | ▲5631 |
| 2015-03-31 | 0.06 | -0.02 | -26.71% | ▼6330 |
| 2014-12-31 | 0.08 | 0.03 | 36.59% | ▲9713 |
| 2014-09-30 | 0.04 | -0.03 | -60.54% | ▼3937 |
| 2014-06-30 | 0.06 | -0.01 | -21.17% | ▲8991 |
| 2014-03-31 | 0.03 | -0.03 | -111.08% | ▼5362 |
| 2013-12-31 | 0.04 | -0.02 | -57.46% | ▲4672 |
| 2013-09-30 | 0.02 | -0.02 | -104.18% | ▼7759 |
| 2013-06-30 | 0.04 | -0.01 | -26.58% | ▼2273 |
| 2013-03-31 | 0.04 | -0.00 | -3.86% | ▲941 |
| 2012-12-31 | 0.02 | -0.00 | -13.27% | ▲31118 |
| 2012-09-30 | 0.01 | -0.04 | -324.45% | ▼32190 |
| 2012-06-30 | 0.05 | -0.00 | -2.55% | ▲10072 |
| 2012-03-31 | 0.02 | -0.02 | -103.27% | ▼4144 |
| 2011-12-31 | 0.03 | -0.02 | -61.83% | ▲6795 |
| 2011-09-30 | 0.02 | -0.03 | -129.78% | ▼5772 |
| 2011-06-30 | 0.02 | -0.02 | -72.07% | ▲2248 |
| 2011-03-31 | 0.02 | -0.02 | -94.55% | ▼4161 |
| 2010-12-31 | 0.03 | -0.01 | -52.94% | ▼943 |
| 2010-09-30 | 0.03 | -0.01 | -43.51% | ▲6352 |
| 2010-06-30 | 0.02 | -0.03 | -107.02% | ▼7475 |
| 2010-03-31 | 0.03 | -0.01 | -32.27% | ▼1071 |
| 2009-12-31 | 0.03 | -0.01 | -21.57% | ▲2170 |
| 2009-09-30 | 0.03 | -0.01 | -43.26% | ▼3445 |
| 2009-06-30 | 0.03 | -0.00 | -8.81% | ▼59855 |
| 2009-03-31 | 0.03 | 0.19 | 589.75% | ▲63165 |
| 2008-12-31 | 0.02 | -0.01 | -41.91% | ▼4738 |
| 2008-09-30 | 0.03 | 0.00 | 5.47% | ▲1806 |
| 2008-06-30 | 0.03 | -0.00 | -12.58% | ▲1891 |
| 2008-03-31 | 0.02 | -0.01 | -31.49% | ▼335 |
| 2007-12-31 | 0.02 | -0.01 | -28.13% | ▼7992 |
| 2007-09-30 | 0.04 | 0.02 | 51.79% | ▲34091 |
| 2007-06-30 | 0.00 | -0.01 | -289.12% | ▲24231 |
| 2007-03-31 | 0.00 | -0.01 | -531.43% | ▼41300 |
| 2006-12-31 | 0.01 | -0.01 | -118.43% | ▲25369 |
| 2006-09-30 | 0.00 | -0.01 | -372.12% | ▼32247 |
| 2006-06-30 | 0.00 | -0.00 | -49.65% | ▲30292 |
| 2006-03-31 | 0.00 | -0.02 | -352.56% | ▼29851 |
| 2005-12-31 | 0.01 | -0.01 | -54.05% | ▲14939 |
| 2005-09-30 | 0.01 | -0.02 | -203.43% | ▼1783 |
| 2005-06-30 | 0.01 | -0.02 | -185.60% | ▲21292 |
| 2005-03-31 | 0.01 | -0.03 | -398.52% | ▲10688 |
| 2004-12-31 | 0.01 | -0.06 | -505.40% | ▼14570 |
| 2004-09-30 | 0.01 | -0.03 | -359.71% | ▼9608 |
| 2004-06-30 | 0.01 | -0.03 | -263.63% | ▼4981 |
| 2004-03-31 | 0.01 | -0.03 | -213.82% | ▲4781 |
| 2003-12-31 | 0.01 | -0.03 | -261.62% | ▼6503 |
| 2003-09-30 | 0.01 | -0.02 | -196.59% | ▼4277 |
| 2003-06-30 | 0.02 | -0.02 | -153.82% | ▲2015 |
| 2003-03-31 | 0.01 | -0.02 | -173.98% | ▼10156 |
| 2002-12-31 | 0.02 | -0.02 | -72.41% | ▲1417 |
| 2002-09-30 | 0.02 | -0.02 | -86.58% | ▲1743 |
| 2002-06-30 | 0.02 | -0.02 | -104.01% | ▼394 |
| 2002-03-31 | 0.02 | -0.02 | -100.07% | ▼2821 |
| 2001-12-31 | 0.02 | -0.02 | -71.86% | ▼805 |
| 2001-09-30 | 0.02 | -0.01 | -63.81% | ▲23971 |
| 2001-06-30 | 0.01 | -0.02 | -303.52% | ▲18962 |
| 2001-03-31 | 0.00 | -0.02 | -493.14% | ▼29849 |
| 2000-12-31 | 0.01 | -0.02 | -194.64% | ▼16505 |
| 2000-09-30 | 0.02 | -0.01 | -29.59% | ▲17516 |
| 2000-06-30 | 0.01 | -0.01 | -204.75% | ▲24732 |
| 2000-03-31 | 0.00 | -0.02 | -452.07% | ▼26681 |
| 1999-12-31 | 0.01 | -0.02 | -185.26% | ▼6828 |
| 1999-09-30 | 0.01 | -0.01 | -116.98% | ▲11219 |
| 1999-06-30 | 0.01 | -0.02 | -229.17% | ▼3826 |
| 1999-03-31 | 0.01 | -0.01 | -190.91% | ▲2883 |
| 1998-12-31 | 0.01 | -0.02 | -219.74% | ▼21471 |
| 1998-09-30 | 0.02 | -0.00 | -5.03% | ▲23291 |
| 1998-06-30 | 0.01 | -0.01 | -237.93% | ▼3966 |
| 1998-03-31 | 0.01 | -0.01 | -198.28% | ▼8232 |
| 1997-12-31 | 0.01 | -0.01 | -115.96% | ▼9850 |
| 1997-09-30 | 0.01 | -0.00 | -17.46% | ▲14461 |
| 1997-06-30 | 0.01 | -0.01 | -162.07% | ▲2489 |
| 1997-03-31 | 0.00 | -0.01 | -186.96% | ▼6039 |
| 1996-12-31 | 0.01 | -0.01 | -126.56% | ▼892 |
| 1996-09-30 | 0.01 | -0.01 | -117.65% | ▲3767 |
| 1996-06-30 | 0.00 | -0.01 | -155.32% | ▼7563 |
| 1996-03-31 | 0.01 | -0.01 | -79.69% | — |
* Basis Point (bps) change measures sequential efficiency shifts. 100 bps = 1.00% Margin change.